Preventing a Perm with TRPV3

Preventing a Perm with TRPV3

Epidermal growth factor receptor (EGFR) signaling is instrumental for terminal differentiation of keratinocytes, hair morphogenesis, and maintenance of the skin barrier. Cheng et al. (2010) now demonstrate that the calcium-permeable channel TRPV3 is required for these EGFR-dependent functions.

TRPV3 in Drug Development

Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP (Transient Receptor Potential) super-family. It is a relatively underexplored member of the thermo-TRP sub-family (Figure 1), however, genetic mutations and use of gene knock-outs and selective pharmacological tools are helping to provide insights into its role and therapeutic potential. TRPV3 is highly expressed in skin, w...

Glycine receptor antibodies in PERM: a new channelopathy.

of dopaminergic neurons of the ventral tegmental area is mediated by protein kinase C. Neuropsychopharmacology 2012; 37: 543–56. Parkinson Study GroupPhase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson’s disease (STEADY-PD). Mov Disord 2013; 28: 1823–31. Puopolo M, Binshtok AM, Yao GL, Oh SB, Woolf CJ, Bean BP. P...

Distinct quenching by TRPV3 ligands

TRPV3 is a thermosensitive ion channel primarily expressed in epithelial tissues of the skin, nose and tongue. The channel has been implicated in environmental thermosensation, hyperalgesia in inflamed tissues, skin sensitization and hair growth. While TRP channel research has vastly increased our understanding of the physiological mechanisms of nociception and thermosensation, the molecular me...

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